About Jonathan Plehn, MD

Jonathan Plehn, MD earned his Doctorate in Medicine from New York University School of Medicine and completed an internship and residency at Montefiore Hospital, University of Pittsburgh before completing his cardiology fellowship at Rush-Presbyterian-St. Luke’s Medical Center in Chicago with further training at Boston University School of Public Health. Dr. Plehn has a wide range of therapeutic trial experience in the areas of lipid therapy, congestive heart failure and the design and management of cardiovascular outcomes trials.

Improve Clinical Trial Statistical Power With Proactive Data Pooling

To drive change, medicine requires hard data to supply evidence of clinical benefit. However, the studies we rely on to make decisions about a drug’s efficacy are often statistically underpowered – that is, therapeutic trials may fail to show the benefit of agents or devices when a benefit does, in fact, exist. This is due to limited data from smallCovance Workers In Lab Blogpatient populations or too much variability in the data.

We performed analyses of studies of anticoagulation in electrical cardioversion to examine this problem more clearly. We also show how proactive data pooling could help to mitigate limitations in statistical power. Continue reading