About Darren Kidd, PhD, Chris Rothwell, BSc, Debbie Henderson, BSc

Darren Kidd, PhD Research Associate, In Vitro Toxicology Technologies Chris Rothwell BSc Technical Specialist, In Vitro Toxicology Assays Debbie Henderson, BSc Manager, Strategic Initiatives About the writers: Ms. Henderson and Dr. Kidd have extensive experience in in vitro toxicology/ alternative methods.. Mr Rothwell has extensive cell culture and flow cytometry experience. The team has most recently validated three in vitro assays for skin sensitization: • Direct Peptide Reactivity Assay (DPRA) • ARE-Nrf2 Luciferase Test Method (KeratinoSens™) • human Cell Line Activation Test (h-CLAT)

REACH a Better Solution: in vitro Skin Sensitization Assays as Animal Testing Alternatives

REACH a Better Solution: in vitro Skin Sensitization Assays as Animal Testing Alternatives

Skin sensitization testing is a major gap for many companies addressing the 2018 REACH substance registration deadline. Join us for a Q&A session with our Covance experts as we review REACH requirements and focus on a better solution for skin sensitization studies: in vitro assays as new alternatives to animal testing.

Q: What do REACH regulations hope to achieve?

A: The European Regulation on Registration, Evaluation, Authorization and Restriction of Chemicals (REACH) places responsibility on companies to assess and manage risks posed by chemicals. They also have to provide appropriate safety information to users. The first purpose is to ensure protection of human health and the environment. Next, the regulation promotes using alternatives to animal test methods. Third, it seeks free circulation of substances to the market, with enhanced competitiveness and innovation. Continue reading