Harnessing Public Involvement for Faster, Lower Cost Trials in Dementia

neuroscience graphicThere should be no doubt that clinical trials in Alzheimer’s disease and dementia need to be faster and more cost-effective if new treatments are to reach patients.

Public interest in participation in clinical trials for dementia is growing as governments become more vocal about the need to find treatments. A number of well-known organizations have well-established processes for linking patients with clinical trials. Alzheimer’s Association’s Trialmatch in the US and the United Kingdom’s Clinical Research Network (UKCRN) Study Portfolio allow patients to search for trials that they would like to participate in. In the case of dementia however, the disease may hinder a person’s ability to search for trials, potentially limiting access to experimental treatments. As research focuses more on prevention of Alzheimer’s it is important to include people interested in research who have no symptoms of memory loss. Continue reading

Delivering Globally Consistent Data from In-House ANA-IFA Assays

Fluorescent micrograph of an ANA-IFA slide.

Image used with permission – Bio-Rad Laboratories and the University of Washington

Simply meeting regulatory standards is not enough for you to remain competitive in today’s evolving immune-mediated inflammatory disease (IMID) drug market. When it comes to FDA approval and successful commercialization of IMID drugs, the consistency of your data is critical. In addition, biopharmaceutical companies such as yours need the ability to detect and quantify small effects, secondary results, potential additional indications, and other insights that can enhance the value of your products.

Covance Central Laboratory Services (Covance CLS) offers extensive in-house capabilities and dedicated support for a variety of key assays used in IMID trials to ensure you obtain unmatched data consistency. One such assay that we perform in-house is the Anti-Nuclear Antibody Indirect Fluorescence Assay, or ANA-IFA – a sensitive screening test used to detect autoimmune diseases. Continue reading

Managing Drug Development Challenges for Inflammation Therapies

InflammationIncorporating technologies such as biomarkers into the development of inflammation therapies can improve the development and delivery of the right therapy, at the right dose, to the right patient. Nonetheless, there are numerous risk factors inherent in inflammation studies and drug development overall. It’s crucial to identify these risks early on in your development plan and develop mitigation strategies that will help decrease your chances for failure. Continue reading

Identifying Challenges and Proposing Solutions in Conducting Alzheimer’s Disease Clinical Trials

AlzheimersWith Alzheimer’s disease increasing across the globe, the demand for preventative, disease-modifying, and curative treatments is mounting. However, there remain several obstacles, including a high failure rate in Alzheimer’s disease clinical trials.

Given the pressing need for Alzheimer advances, Covance recently surveyed 100 of the most experienced investigators (throughout 25 countries) involved in Alzheimer’s research to gain perspectives that may be critical in planning for successful trials in the future. The majority of investigators included were physicians from large academic institutions, hospitals, and clinics, including neurologists and psychiatrists. Also represented were physicians with a specific focus on Neurogeriatrics, Clinical Pharmacology, and other related specialties. Continue reading