Quantify T Cell Biodistribution Non-Invasively in Animal and Human Subjects

Covance is looking for expressions of interest from companies involved in CAR-T and T Cell Receptor therapies, regarding non-invasive cell tracking in vivo.  Covance is using a validated MRI platform that can be used to label T cells and detect/track cells in rodents.1  This strategy can also be implemented in NHP studies and clinical trials.2 The following can be quantified over time in living subjects:

  • Tissue residence times/persistence
  • Cell viability
  • Engraftment patterns
  • Clearance pathways
  • Efficacy correlation with cell biodistribution

Please contact us today for more information.

Written by: Patrick McConville, PhD

1Srinivas at al., In Vivo Cytometry of Antigen-specific T Cells Using 19F MRI, Magn Reson Med. 2009 Sep;62(3):747-53. doi: 10.1002/mrm.22063.
2Ahrens et al., Clinical Cell Therapy Imaging Using a Perfluorocarbon Tracer and Fluorine-19 MRI, Magn Reson Med. 2014 Dec;72(6):1696-701. doi: 10.1002/mrm.25454. Epub 2014 Sep 19.