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Covance Blog
Although most physiochemical endpoints are standard for crop and chemical active substances, selection of the right test method to assess them is critical. This blog reviews some standard endpoints and looks at the tests used, in the light of changing regulatory expectations and revised test methodologies for difficult substances.
What is DART? DART stands for ‘developmental and reproductive toxicology’ and is the acronym commonly used in place of the term reproductive toxicology. DART studies assess a chemical’s effect on several aspects of reproductive capacity in laboratory animals. These include mating performance and fertility, sexual maturation, and offspring growth and …
The COVID-19 pandemic is driving a global demand for medical supplies, equipment and cleaning agents. In terms of PPE alone, the WHO estimates that there is a world-wide monthly demand for 89 million medical masks, 76 million examination gloves and 1.6 million goggles. To meet this demand, the WHO suggests …
An unprecedented challenge The COVID-19 pandemic has increased the demand for hand disinfectants, driven by recommendations from bodies such as the WHO. Handwashing is a vital measure for reducing the risk of contracting the virus. The WHO specifically recommends that all individuals “regularly and thoroughly clean (their) hands with an …
In 2015, South Korea introduced legislation designed to protect human health and the environment from the impact of chemicals. With an estimated 44,000 chemicals in use in South Korea and about 300 new chemicals marketed annually, registrants and regulators will be kept busy assessing the risk posed to humans, animals …
Environmental fate (eFate) studies are well established for crop protection chemicals and pharmaceuticals and are becoming commonplace for industrial chemicals, but what are the key considerations for setting up and running them?
The new EU nanotechnology regulation On December 3, 2018, the European Commission (EC) adopted Regulation 2018/1881, amending the existing , amending the existing Registration, Evaluation, Authorization and Restriction of Chemicals (REACH) regulation, to directly address nanoparticles. The nanotechnology regulation applies to any substance that might be, or might contain, a …
The last REACH deadline was in May 2018 and brought to a close the period of active information gathering on the safety of chemical products marketed in the EU/EEA. It has resulted in a massive database of safety information on a wide range of substances and heralds an exciting new …
Introduction Neonicotinoids were developed to find safer, more effective alternatives to chlorinated hydrocarbons, organophosphates, carbamates, and pyrethroids, so, ironically, some neonicotinoids are now banned in the EU because of their toxicity to bees and other pollinators, as well as to a wider group of species. The agricultural and environmental consequences …
Avoiding obstacles with REACH Annexes VII-X Posted by Dr. David Howes, Expert Consultant in Chemical Legislation and Chemistry, Covance In the EU, the Registration, Evaluation, Authorization and Restriction of Chemicals (REACH) regulations address the manufacturing and import of chemicals to ensure they are safe for human health and the environment. …