Clinical Testing Archives - Insights From Our Labs to Yours

What Child Health Day means to me: Gina Calarco shares her story

by Gina Calarco, MPH, BSN, RN, CCRCupdated on Tuesday, June 2, 2020Tuesday, October 2, 2018

On National Child Health Day, and every day, I feel grateful for the work I do at Covance, and how it impacts the lives and health of children. I also recognize this event as an opportunity to spread knowledge about the work still remaining.

Immuno-Oncology Studies: Optimizing Design, Recruitment and Execution

by Suso Platero, Ph.D.updated on Monday, February 17, 2020Wednesday, November 15, 2017

The rise of immunotherapy has been meteoric — there are now well more than 1,000 immuno-oncology (IO) trials ongoing according to clinicaltrials.gov. Finding and enrolling the appropriate patients for these potentially revolutionary treatments has presented a profound challenge, one that was recently covered in the aptly titled New York Times …

Can We Expand Companion Diagnostics Beyond Oncology?

by Thomas Turi, PhDupdated on Monday, February 17, 2020Wednesday, November 1, 2017

The majority of today’s approved companion (and complementary) diagnostics (CDx) support personalized medicine efforts in oncology, a testament to researchers’ growing knowledge regarding the genetic pathways impacted in various cancers. That understanding increases our ability to convert such knowledge of biology into treatments that specifically target disease based on a …

Covance Central Laboratory Services in Shanghai Helps Clients Navigate Chinese Regulatory Reform

by Covance by Labcorpupdated on Sunday, March 29, 2020Wednesday, July 19, 2017

Following the rebrand and restructure of the Chinese regulatory body, the China Food and Drug Administration (CFDA), in 2013, the regulation process now includes inspections for all multi-national and local pharmaceutical companies with drug filings in China. As a continued commitment to meet clients’ needs and conform to local Chinese …

ELISPOT Assay: A Powerful Tool in Vaccine Development and Immune Monitoring

by Sinnathamby Gomathinayagam, Ph.D.updated on Monday, February 17, 2020Thursday, June 1, 2017

Over the past several years, the scientific community has made tremendous progress in advancing our understanding of the immune system, from the basic functions of its various components to molecular pathways that operate within those components. With new, state-of-the-art tools and technologies, immunologists now have the ability to better understand the …

Attracting Naïve Patients to RA Clinical Studies

Finding the Other 90%: Attracting Naïve Patients to RA Studies

by Martin Knight BScupdated on Monday, February 17, 2020Thursday, May 25, 2017

A recent study by Tufts Center for the Study of Drug Development, based on a survey of 2,000 physicians and nurses primarily in the United States and Europe, found that 91% of physicians feel ‘somewhat’ or ‘very’ comfortable discussing the opportunity to participate in a clinical trial with patients, but …

Getting Investigators Onboard: Lab Preferences Make a Difference in Trial Participation

by Covance by Labcorpupdated on Friday, October 18, 2019Tuesday, January 17, 2017

Clinical trials are becoming increasingly complex and competitive, so attracting the best investigator sites to participate in a trial is a crucial step in meeting patient enrollment targets. Delaying approval by even one day can cost hundreds of thousands of dollars or more, depending on the drug. This means that …

TQT Waivers: One Year Later

by Covance by Labcorpupdated on Friday, October 18, 2019Wednesday, November 9, 2016

Overcoming Design Challenges ICH E14 REGULATORY GUIDANCE 2005 AND 2015 It has been one year since the International Conference on Harmonisation (ICH) updated its 2005 cardiac safety guidelines. The 2015 update allows for specific QT interval analysis based upon concentration effect modeling up to supratherapeutic during Phase I as a …

Behind the Scenes with Kits & Logistics for Vaccine Studies

by Sarah Slette, Vaccine Study Manager, Vaccine & Novel Immunotherapeutics and Daniel Weaver, Regional Logistics Manager of Covanceupdated on Monday, February 17, 2020Thursday, August 11, 2016

Whether large or small, vaccine studies differ from standard drug development in many ways. Sarah Slette, Sr. Study Manager, Vaccines & Novel Immunotherapeutics at Covance, explains the unique challenges her team faces and their solutions to rapidly deliver customized vaccine kits to sponsors’ sites across the globe.

Developing a Successful Regulatory Strategy for Mobile Health Devices and Applications

by Bill Hanlon, PhD & Scott Thiel, MBA, MT (ASCP)updated on Friday, October 18, 2019Wednesday, June 22, 2016

For many technology companies entering the mobile health space, meeting US Food and Drug Administration (FDA) requirements may be unfamiliar territory. The guidelines can appear convoluted and contradictory at first glance, and some devices and/or applications (apps) fall into regulatory grey areas. To make progress in this rapidly changing field, …