With five global central laboratories, Labcorp understands the value of around-the-clock support to advance clinical trial testing, but the recent 65-day lockdown at their Shanghai facilities gave new meaning to “around the clock.” Understanding the severity of the situation On March 28, 2022, the entire population of Shanghai was suddenly …
Balancing precision and recall in the pharmacovigilance (PV) literature monitoring
What do precision and recall mean in lay terms? In pattern recognition, information retrieval and classification (machine learning), precision and recall are performance metrics that apply to data retrieved from a collection, corpus or sample space. Precision (also called positive predictive value) is the fraction of relevant instances among the retrieved instances, while recall (also known as sensitivity) is the fraction of relevant instances that were retrieved. …
New OECD TG 497: Interpretation and application of defined approaches for skin sensitization assessment
The advent of requiring multiple non-animal in vitro alternatives for skin sensitization assessments has prompted the Organisation for Economic Co-operation and Development (OECD) to publish new guidance to outline the approaches for data interpretation from multiple non-animal test methods. When used together in specific combinations, these methods will aid with …
iCAN focus group highlights need for youth representation in clinical trials
As the name would suggest, patient-centric clinical trials rely on the patient voice. This is especially true in pediatric therapies, where younger patients are engaged to share their unique insights on new investigational products but may be unfamiliar or uncomfortable with advanced clinical trial concepts. As a proud sponsor of …
Expanded laboratories to match your growing needs in vaccine development and antibody reagents
Continued growth in the development of large molecule therapeutics has constrained resources for in vivo studies and in vitro sample analysis. In addition, the COVID-19 pandemic has brought renewed urgency to vaccine research and development, emphasizing a need to protect the world against existing, re-emerging and emerging pathogens and accelerate …
Long COVID Q&A: 4 things to know about COVID cognitive dysfunction
Long COVID is a colloquial term used to describe the lingering health symptoms some patients experience after contracting the COVID-19 virus. While the majority of people fully recover from the virus, some “long-hauler” patients report long COVID symptoms ranging from general fatigue to headaches and brain fog, also known as …
PK, PD and immunogenicity assays to support clinical trials – building the bigger picture
Understanding how a body processes a therapy and a therapy’s effect on the body is a critical step for understanding safety and efficacy to support clinical trials. But the process of characterization differs between small-molecule therapies and biotherapeutics. Associate Director of Early Scientific Engagement at Labcorp Drug Development, Robert Nelson, …
Learn about the latest in Labcorp DCT solutions by connecting with us at regional meetings around the globe – May 2022
Welcome to the May 2022 Labcorp Drug Development Decentralized Clinical Trial (DCT) blog. Because spring is a time traditionally packed with industry conferences, we will devote this blog to reviewing some of the highlights of our plans for the spring conference season. We hope to connect with you at one …
Non-GLP sample analysis for ocular biodistribution studies
Traditional bioanalytical service providers are geared toward analyzing large sets of samples under various regulatory guidelines, such as large nonclinical and clinical studies, which are heavily regulated. This puts a heavy burden on these service providers, creating long lead times, resource constraints and lack of flexibility. Currently, many bioanalytical laboratories …
Welcome to the digital future of pathology
Imagine getting a phone call in the middle of your study from a scientist who is seeing something completely unexpected in your study results. You need to make a decision on how to move forward and you need to do it quickly. You don’t have time to wait for a …