Sunday, December 1
is World AIDS Day, an international day dedicated to raising awareness of the
AIDS pandemic caused by the spread of HIV infection, and a time to remember
those who have died of the disease. It has been observed worldwide since 1988.
Oren Cohen, MD,
Covance Chief Medical Officer, was an infectious disease physician in New York
City during the early days of the epidemic and shares this remembrance:
The majority of today’s approved companion (and complementary) diagnostics (CDx) support personalized medicine efforts in oncology, a testament to researchers’ growing knowledge regarding the genetic pathways impacted in various cancers. That understanding increases our ability to convert such knowledge of biology into treatments that specifically target disease based on a tumor’s genetic makeup. This has led to significantly improved outcomes for many patients.
But can we leverage the knowledge of the biology of other disease states along with the appropriate technical progress into successful CDx expansion beyond oncology? Given that nearly 50% of all compounds in clinical development are dropped for lack of efficacy, CDx may represent a viable approach to improve this statistic and boost the efficiency of drug development efforts. Promising clinical areas where CDx may play an important role include immunology, rare and orphan diseases, and neurodegenerative diseases such as Alzheimer’s disease. Continue reading